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E
| Player | Bats | Throws | Position | Team | Data |
|---|---|---|---|---|---|
| Easley, Damion | - | R | DH | pitcher | batter | |
| Eaton, Adam | - | R | P | Colorado Rockies | pitcher | batter |
| Eaton, Adam | - | L | CF | Arizona Diamondbacks | pitcher | batter |
| Eckstein, David | - | R | 2B | San Diego Padres | pitcher | batter |
| Edgin, Josh | - | L | P | New York Mets | pitcher | batter |
| Edlefsen, Steve | - | R | P | San Francisco Giants | pitcher | batter |
| Edmonds, Jim | - | L | CF | Cincinnati Reds | pitcher | batter |
| Egbert, Jack | - | R | P | New York Mets | pitcher | batter |
| Ekstrom, Mike | - | R | P | Colorado Rockies | pitcher | batter |
| Elarton, Scott | - | R | DH | pitcher | batter | |
| Elbert, Scott | - | L | P | Los Angeles Dodgers | pitcher | batter |
| Eldred, Brad | - | R | 1B | Detroit Tigers | pitcher | batter |
| Elias, Roenis | - | L | P | Seattle Mariners | pitcher | batter |
| Ellis, A.J. | - | R | C | Los Angeles Dodgers | pitcher | batter |
| Ellis, Mark | - | R | 2B | Los Angeles Dodgers | pitcher | batter |
| Ellison, Jason | - | R | DH | pitcher | batter | |
| Ellsbury, Jacoby | - | L | CF | Boston Red Sox | pitcher | batter |
| Elmore, Jake | - | R | 2B | Houston Astros | pitcher | batter |
| Ely, John | - | R | P | Los Angeles Dodgers | pitcher | batter |
| Emaus, Brad | - | R | 2B | New York Mets | pitcher | batter |
| Embree, Alan | - | L | P | Boston Red Sox | pitcher | batter |
| Encarnacion, Edwin | - | R | 1B | Toronto Blue Jays | pitcher | batter |
| Encarnacion, Juan | - | R | DH | pitcher | batter | |
| Englebrook, Evan | - | R | P | Houston Astros | pitcher | batter |
| English, Jesse | - | L | P | Washington Nationals | pitcher | batter |
| Ennis, John | - | R | P | Philadelphia Phillies | pitcher | batter |
| Enright, Barry | - | R | P | Los Angeles Angels | pitcher | batter |
| Ensberg, Morgan | - | R | DH | pitcher | batter | |
| Eovaldi, Nathan | - | R | P | Miami Marlins | pitcher | batter |
| Eppley, Cody | - | R | P | New York Yankees | pitcher | batter |
| Erbe, Brandon | - | R | P | Baltimore Orioles | pitcher | batter |
| Erickson, David | - | R | DH | pitcher | batter | |
| Erickson, Jason | - | R | DH | pitcher | batter | |
| Erlin, Robbie | - | L | P | San Diego Padres | pitcher | batter |
| Erstad, Darin | - | L | LF | Houston Astros | pitcher | batter |
| Erwin, Drew | - | R | P | Philadelphia Phillies | pitcher | batter |
| Escalona, Edgmer | - | R | P | Colorado Rockies | pitcher | batter |
| Escalona, Sergio | - | L | P | Houston Astros | pitcher | batter |
| Escobar, Alcides | - | R | SS | Kansas City Royals | pitcher | batter |
| Escobar, Alex | - | R | DH | pitcher | batter | |
| Escobar, Eduardo | - | R | SS | Minnesota Twins | pitcher | batter |
| Escobar, Kelvim | - | R | P | New York Mets | pitcher | batter |
| Escobar, Yunel | - | R | SS | Tampa Bay Rays | pitcher | batter |
| Espineli, Geno | - | L | DH | pitcher | batter | |
| Espinosa, Danny | - | R | 2B | Washington Nationals | pitcher | batter |
| Esposito, Brian | - | R | C | Houston Astros | pitcher | batter |
| Estes, Shawn | - | L | DH | pitcher | batter | |
| Estrada, Johnny | - | R | DH | pitcher | batter | |
| Estrada, Marco | - | R | P | Milwaukee Brewers | pitcher | batter |
| Estrada, Paul | - | R | DH | pitcher | batter | |
| Ethier, Andre | - | L | RF | Los Angeles Dodgers | pitcher | batter |
| Evans, Nick | - | R | 1B | New York Mets | pitcher | batter |
| Evans, Terry | - | R | CF | Los Angeles Angels | pitcher | batter |
| Eveland, Dana | - | L | P | Baltimore Orioles | pitcher | batter |
| Everett, Adam | - | R | SS | Cleveland Indians | pitcher | batter |
| Everidge, Tommy | - | R | 1B | Oakland Athletics | pitcher | batter |
| Everts, Clint | - | R | P | New York Mets | pitcher | batter |
| Exposito, Luis | - | R | C | Baltimore Orioles | pitcher | batter |
| Eyre, Scott | - | L | P | Philadelphia Phillies | pitcher | batter |
| Eyre, Willie | - | R | P | Baltimore Orioles | pitcher | batter |