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I
| Player | Bats | Throws | Position | Team | Data |
|---|---|---|---|---|---|
| Iannetta, Chris | - | R | C | Colorado Rockies | pitcher | batter |
| Ibanez, Raul | - | R | LF | Philadelphia Phillies | pitcher | batter |
| Ibarra, Jeffrey | - | L | DH | pitcher | batter | |
| Igarashi, Ryota | - | R | P | New York Mets | pitcher | batter |
| Igawa, Kei | - | L | DH | pitcher | batter | |
| Iglesias, Jose | - | R | SS | Boston Red Sox | pitcher | batter |
| Iguchi, Tadahito | - | R | DH | pitcher | batter | |
| Infante, Gregory | - | R | P | Chicago White Sox | pitcher | batter |
| Infante, Omar | - | R | 3B | Florida Marlins | pitcher | batter |
| Inge, Brandon | - | R | 3B | Detroit Tigers | pitcher | batter |
| Inglett, Joe | - | R | RF | Houston Astros | pitcher | batter |
| Inman, William | - | R | DH | pitcher | batter | |
| Iorg, Cale | - | R | SS | Detroit Tigers | pitcher | batter |
| Iorg, Eli | - | R | DH | pitcher | batter | |
| Iribarren, Hernan | - | R | 2B | Milwaukee Brewers | pitcher | batter |
| Irvine, Patrick | - | L | DH | pitcher | batter | |
| Ishikawa, Travis | - | L | 1B | San Francisco Giants | pitcher | batter |
| Isringhausen, Jason | - | R | P | New York Mets | pitcher | batter |
| Italiano, Craig | - | R | P | San Diego Padres | pitcher | batter |
| Ivany, Devin | - | R | DH | pitcher | batter | |
| Iwamura, Akinori | - | R | 3B | Oakland Athletics | pitcher | batter |
| Izturis, Cesar | - | R | SS | Baltimore Orioles | pitcher | batter |
| Izturis, Maicer | - | R | 3B | Los Angeles Angels | pitcher | batter |